王聖帆  助理教授                             

Sheng-Fan Wang, Assistant Professor

研究室: 濟世大樓 CS607/國際學術大樓-傳染病與癌症研究中心

電話: 07-3121101  ext. 2558 or 2354

Email: wasf1234@kmu.edu.tw

學歷:

國立陽明大學 醫學生物技術暨檢驗學系 博士 ( 2005-2009)

國立陽明大學 醫學生物技術研究所 碩士 (1999-2001)

國立陽明大學 醫事技術學系 學士 (1995-1999)

經歷

中央研究院 生物醫學研究所 博士後研究 (2010-2014)

國立陽明大學 醫學檢驗暨生物技術學系 博士後研究 (2009- 2010)

行政院衛生部疾病管制署 國防訓儲人員 (2001-2005)

獎勵

中央研究院生物醫學研究所 最佳論文獎 (2013)

中華民國斐陶斐獎 (2009)

陽明大學發展國際一流大學獎學金補助 (2009)

第15屆國際愛滋病研討會獎學金 (2004)

學術專長

病毒學、臨床病毒學、醫學生物技術

研究興趣

愛滋病毒(HIV-1)與半乳糖凝集素-3 (Galectin-3)的相關性、流行性感冒(Influenza virus)與其它呼吸道病毒在病毒學與免疫學上研究、抗病毒藥物的開發、病毒抗藥性、興新傳染病(Emerging Infectious Disease)研究

國際期刊論文著作 (SCI):

1. Szu-Hao Kung, Sheng-Fan Wang, Chaio-Wei Huang, Chiu-Chu Hsu, Hsin-Fu Liu,
2. Sheng-Fan Wang, Jason C. Huang, Yuan-Ming Lee, Shih-Jen Liu, Yu-Jiun Chan,
3. Sheng-Fan Wang, Kuan-Hsuan Chen, Arunee Thitithanyanont, Ling Yao, Yuan-Ming, Lee, Yu-Jiun Chan, Shih-Jen Liu, Pele Chong, Wu-Tse Liu, Jason C. Huang, and Yi-Ming Arthur Chen. Generating and Characterizing Monoclonal and Polyclonal Antibodies against Avian H5N1 Hemagglutinin Protein. Biochem Biophys Res Commun. 2009,382(4):691-696.
4. Sheng-Fan Wang, Yuan-Ming Lee,Yu-Jiun Chan, Hsin-Fu Liu,Yung-Fong Yen,
5. Yuan-Ming Lee, Sheng-Fan Wang, Cheng-Ming Lee, Kuan-Hsuan Chen, Yu-Jiun
6.  Sheng-Fan Wang,Ling Yao,Shih-Jen Liu, Pele Chong, Yi-Ming Arthur Chenand Jason C. Huang. Identifying Conserved DR1501-restricted CD4⁺ T cell Epitopes in Hemagglutinin Proteins after H5N1 Vaccine Inoculation.  Viral Immunology;2010 Dec..
7. Ying-Feng Chang*,and Sheng-Fan Wang*,Jason C. Huang*,Li-Chen Su, Ying-Chen Li, Cheng-Chung Lee, Ling Yao,Yi-Ming A. Chen, andChien Chou. Detection of Swine-origin Influenza A (H1N1) Viruses Using a Localized Surface Plasmon Coupled Fluorescence Fiber-optic Biosensor. (*equal contribution) Biosensors and Bioelectronics; 2010 ;26(3):1068-73.
8.  Che-Feng Liao*,Sheng-Fan Wang*,Yu-Ting Lin,and Yi-Ming Arthur Chen. Identification of the DC-SIGN-interactive domains on the envelope glycoprotein of HIV-1 CRF07_BC. (*equal contribution)AIDS Research and Human Retroviruses; 2011, 27(8): 831-839.
9. Yuan-Ming Lee; Huang-Jie Lin; Yen-Ju Chen; Cheng-Ming Lee; Sheng-Fan Wang; Kai-Yuan Chang; Tzu-Lang Chen; Hsin-Fu Liu; Yi-Ming Arthur Chen. Molecular epidemiology of HCV genotypes among injection drug users in Taiwan: Full-length sequences of two new subtype 6w strains and a recombinant form_2b6w.Journal of medical virology 2010;82(1):57-68
10. Chun-Wei Lee, Shr-Jeng Jim Leu, Ruei-Ying Tzeng, Sheng-Fan Wang,
11.  Sheng-Fan Wang,  Kuan-Hsuan Chen, Yen-Ju Chen,  Wen-Yi Lee,  Marcelo Chen, Jason C. Huang, Yi-Ming Arthur Chen. Human-Leukocyte-Antigen Class I Cw 1502 and Class II DR 0301 Genotypes are Associated with Resistance to Severe Acute Respiratory Syndrome (SARS) Infection.  Viral Immunology, 2011, 24(5): 421-426.
    1. Hoa Minh Luong*, Sheng-Fan Wang*, Vu Tan Trao, Suh-Chin Wu, Marcelo Chen, Jason C. Huang, Phung Dac Cam, Yi-Ming Arthur Chen. Retrospective survey of avian influenza H5N1 infection in Northern Vietnam by using a combinational serologic assay. (*equal contribution) Health, 4, 974-982.
    2. Wang S.F , Yang C.Y , Tseng T.C , Chen H.Y.   Molecular Biological Analysis of the First Imported Rabies Case in Taiwan . Taiwan Epidemiology Bulletin2002 ; October 25 , Vol. 18 , No. 10 : 245-255.
    3. Wang S.F, Lin C.L , Yang C.Y.  Establishment of Real-time PCR Analysis System to detect Enterovirus infection . Taiwan Epidemiology Bulletin 2002 ; November 25 , Vol. 18 , No. 11 : 267-277.
    4. Hsu L.C , Hsu F.K , Chang S.F , Chou L , Wang S.F , Yang S.Y.  Establishing a Yellow Fever Serological Testing Method .Taiwan Epidemiology Bulletin 2003; March 25 , Vol. 19 , No. 3 : 47-59.
    5. Wang S.F, Yang C.Y , Lee H.C , Chen .H.Y . Molecular Biological Analysis of SARS Virus in Taiwan . Taiwan Epidemiology Bulletin2003; June 25 , Vol. 19 , No. 6 : 127-141
    6. Wang S.F, Lee H.C , Chen H.Y , Yang J.Y.  Establishment and Analysis of SARS Real-time Quantitative System . Taiwan Epidemiology Bulletin2003; July 25 , Vol. 19 , No. 7 :153-168
    7. Cheng WY, Wang S.F, Yang C.Y, Chen H.Y. Genotype Analysis of Measles Virus ,2002. Taiwan Epidemiology Bulletin2003; Oct 25 , Vol. 19 , No. 10 : 231-243.
    8. Wang S.F , Yang J.Y ,Chen H.Y.  Analysis and testing for AIDS in 92 Homosexuals at a Private Party . Taiwan Epidemiology Bulletin
    9. Wang S.F, Liu S.C, Lee H.C, Wu P.J, Hsu C.C, Wang S.H, Huang Y.F, Tsai S.F, Yang J.Y, Chen H.Y Molecular Biology Confirmation and Analysis of Suspected Transfusion-Associated HIV Cases. Taiwan Epidemiology Bulletin
    10. Wang S.F, Lu S.J, Lee H.C, Wang S.Z, Shu C.J, Wang S.H, Huang Y.F, Tsai S.F, YangJ.Y, Chen H.Y Subtype Identification and Drug-Resistant Point Mutation of Human Immunodeficiency Virus Type I in Taiwan. Taiwan Epidemiology Bulletin
    11. Wang S.F, Lin T.L, Hsu C.C, Lee H.C, Luo S.J, Huang C.W, Yang J.Y, Chen H.Y An Epidemiological Analysis of Enterovirus 71: Taiwan, 1998-2004. Taiwan Epidemiology Bulletin
    12. , W.W.Wong , Y.J.Chan and W. T. Liu. Genotyping and Phenotyping of Human Immunodeficiency Virus Type 1 by Protease Inhibitor Testing. XIV International AIDS Conference 2002 , Barcelona.
    13. , Yang J.Y and Liu W.T.  Propagation of SARS Coronavirus with human promonocyte cell line, HL-CZ. The 6 th Asia Pacific Congress of Medical Virology , Nov 2003.
    14. , J.C. Huang, P. Chong, Y.M Chen. DC-SIGN Mediates Avian H5N1 Influenza Virus Infection in Cis and in Trans. Taiwan Society and Microbilogy and 11th Western Pacific Congress on Chemotherpay and Infectious Disease (WPCCID) (Nov.29-Dec.9, 2008)
    15. . Virological investigation of four outbreaks of influenza B reassortants in thenorthern region of Taiwan from October 2006 to February 2007. Taiwan Society and Microbilogy and 11th Western Pacific Congress on Chemotherpay and Infectious Disease (WPCCID) (Nov.29-Dec.9, 2008).

Jyh-Yuan Yang. Genetic and antigenic analyses of enterovirus 71 isolates in

Taiwan during 1998-2005. Clin Microbiol Infect. 2007;13(8):782-787.

Yat-Pang Chau, Pele Chong and Yi- Ming Arthur Chen. DC-SIGN mediates avian

H5N1 influenza virus infection in cis and in trans. Biochem Biophys Res

Commun. 2008,373(4):561-566.

Wu-Tse Liu, Jason C. Huang, Yi- Ming Arthur Chen Influenza A virus in Taiwan,

1980-2006: Phylogenetic and Antigenic Characteristics of the Hemagglutinin

Gene. Journal of Medical Virology. 2009 Aug;81(8):1457-70.

Chan, Wu-Tse Liu and Yi- Ming Athur Chen. Virological investigation of four

outbreaks of influenza B reassortants in the northern region of Taiwan from

October 2006 to February 2007. BMC research Note. 2009, 9;2(1):86.

Shu-Chun Tsai, Kuang-Hui Sun, Ruey-Hwa Chen, Jason C. Huang

Latent membrane protein 1 of Epstein–Barr virus regulates death-associated protein kinase 1 in lymphoblastoid cell line. Virology2011 Apr. 413 (2011) 19–25.

12. Lee YM, Chuang SY, Wang SF, Lin YT, Chen YM., Epidemiology of human herpesvirus type 8 and parvovirus B19 infections and their association with HIV-1 among men who have sex with men and injection drug users in Taiwan.

   J Microbiol Immunol Infect. 2013 Mar 3. pii: S1684-1182(13)00021-2.

國內期刊論文著作:

專書著作:

1. Sheng-Fan Wang and Yi-Ming Arthur Chen. The Interactions between Avian

H5N1 Influenza Virus and Dendritic Cell-Specific ICAM-3 Grabbing

Non-Integrin (DC-SIGN). Chapter 6, Global View at Fight against Influenza,

Nova Science Publishers.

2. Sheng-Fan Wang and Yi-Ming Arthur Chen. The Emergence of HIV-1 Circulating

Recombinant Form 07_BC Strains in Taiwan. Emerging Infectious Diseases:

Global Trends, Surveillance and Eradication, Nova Science Publishers.

3. 醫學分子檢驗 ( Molecular Diagnosis Medicine), 王聖帆等著作五南出版社

研討會發表論文:

1. , Y.M Lee, J.C Huang, Y.M Chen.Phylogenetic and antigenic analysis of human influenza A virus hemagglutiningene during 1980-2006 in Taiwan.The 8th Asia-Pacific Congress of Medical Virology (Hong Kong, 25-28 Feb 2009).

6. S.F Wang, L.Yao, S.J Liu, P. Chong, Y.M.Chen,J. Huang, W.T Liu. Identifying the B cell and DR-1501 restricted CD4⁺ T cell epitopes of Hemagglutinin proteins in the avian H5N1 virus. BIT’s 1^st World Congress of Virus and Infections 2010 (July 31-August 3, 2010 Venue:Busan Exhibition & Convention Center, Korea)

7. S.-F. Wang, C.-H. Tsao, Y.-T. Lin, M.-L. Chiang, F.-C. Chien, P. Chen, D. Hsu, Y.-M. Chen, H.-Y. Chen, F.-T. Liu. Galectin-3 promotes virus budding and cell-to-cell transmission of HIV-1. ^7thIAS Conference on Pathogenesis, Treatment and Prevention (Jul 30-Jun 3, 2013, Kuala Lumpur Malaysia)

專利 (Patent):

1.半乳糖凝集素-3的N片段能抑制HIV-1病毒的出芽 (創作人：劉扶東、陳煥源、王聖帆)

專利編號: 12A-1020422。