Pei-Ching Chang

Get in Touch

• Tel: +886-2-2826-7111

Email: pcchang@ym.edu.tw

Specialty

1. Molecular Biology
2. Tumor Biology
3. Biochemistry
4. Organic chemistry
5. Molecular Toxicology

Education

Crossed Appointments

Academic Honors and Awards

Dr. Chien-Tien Hsu’s Award in Fourteenth Symposium on Recent Advances in Cellular and Molecular Biology

Publications

Journal articles(*co-corresponding author)

1. P.C. Chang*, T.Y. Wang, Y.T. Chang, C.Y. Chu, C.L. Lee, H.W. Hsu, T.A. Zhou, Z. Wu, R.H. Kim, S.J. Desai, S. Liu, H.J. Kung. “Autophagy Pathway Is Required for IL-6 Induced Neuroendocrine Differentiation and Chemoresistance of Prostate Cancer LNCaP Cells.” PLoS One (Feb 2014)
2. C.Y. Cheng, C.H. Chu, H.W. Hsu, F.R. Hsu, C.Y. Tang, W.C. Wang, H.J. Kung, P.C. Chang. “An improved ChIP-seq peak detection system for simultaneously identifying post-translational modified transcription factors by combinatorial fusion, using SUMOylation as an example.” BMC Genomics (Jan 2014)
3. P.C. Chang, C.Y. Cheng, M. Campbell, Y.C. Yang, H.W. Hsu, T.Y. Chang, C.H. Chu, Y.W. Lee, C.L. Hung, S.M. Lai, C.G. Tepper, W.P. Hsieh, H.W. Wang, C.Y. Tang, W.C. Wang, H.J. Kung. “The chromatin modification by SUMO-2/3 but not SUMO-1 prevents the epigenetic activation of key immune-related genes during Kaposi's sarcoma associated herpesvirus reactivation.” BMC Genomics (Nov 2013) *co-corresponding author
4. M. Campbell, K.Y. Kim, P.C. Chang, S. Huerta, B. Shevchenko, D.H. Wang, C. Izumiya, H.J. Kung, Y. Izumiya. “A Lytic Viral Long Non-coding RNA Modulates the Function of a Latent Protein” J Virol. (Nov 2013)
5. M. Campbell, P.C. Chang, S. Huerta, C. Izumiya, R. Davis, C.G. Tepper, K.Y. Kim, B. Shevchenko, D.H. Wang, J.U. Jung, P.A. Luciw, H.J. Kung, Y. Izumiya. “Protein Arginine Methyltransferase 1-directed Methylation of Kaposi Sarcoma-associated Herpesvirus Latency-associated Nuclear Antigen” J Biol Chem. (Feb 2012)
6. P.C. Chang, L.D. Fitzgerald, D.A. Hsia, Y. Izumiya, C.Y. Wu, W.P. Hsieh, S.F. Lin, M. Campbell, K.S. Lam, P.A. Luciw, C.G. Tepper, H.J. Kung “Histone demethylase JMJD2A regulates Kaposi's sarcoma-associated herpesvirus replication and is targeted by a viral transcriptional factor” J Virol. (Apr 2011)
7. P.C. Chang, Y. Izumiya, C.Y. Wu, L.D. Fitzgerald, M. Campbell, T.J. Ellison, K.S. Lam, P.A. Luciw, H.J. Kung “Kaposi's sarcoma associated herpesvirus (KSHV) encodes a SUMO E3 ligase which is SIM-dependent and SUMO-2/3-specific” J Biol Chem (Feb. 2010)
8. Z. Wu, P.C. Chang, J.C. Yang, C.Y. Chu, L.Y. Wang, N.T. Chen, A.H. Ma, S.J. Desai, S.H. Lo, C.P. Evans, K.S. Lam, and H.J. Kung “Autophagy Blockade Sensitizes Prostate Cancer Cells towards Src Family Kinase Inhibitors” Genes & Cancer (Jan. 2010)
9. P.C. Chang, L.D. Fitzgerald, A. Van Geelen, Y. Izumiya, T.J. Ellison, D.H. Wang, D.K. Ann, P.A. Luciw, and H.J. Kung “KRAB domain-associated protein-1 as a latency regulator for Kaposi’s sarcoma-associated herpesvirus and its modulation by the viral protein kinase” Cancer Res (July 2009)
10. P.C. Chang and M. Li “Kaposi's sarcoma-associated herpesvirus K-cyclin interacts with Cdk9 and stimulates Cdk9-mediated phosphorylation of p53 tumor suppressor” J Virol, (Jan. 2008)
11. Y.L. Lin, P.C. Chang, Y. Wang, and M. Li “Identification of novel viral interleukin-10 isoforms of human cytomegalovirus AD169” Virus Res, (Feb. 2008)
12. P.C. Chang, C.W. Chi, G.Y. Chau, F.Y. Li, Y.H. Tsai, J.C. Wu and Y.H.W. Lee “DDX3, a DEAD box RNA helicase, is deregulated in hepatitis virus associated hepatocellular carcinoma and is involved in cell growth control” Oncogene, (Mar. 2006)
13. W.F. Chiou, P.C. Chang, C.I. Chou, C.F. Chen “Protein constituent contributes to the hypotensive and vasorelaxant activities of Cordyceps Sinensis ” Life Sciences, (Feb. 2000)