Jonathan D. Powell, M.D., PhD.

Get in Touch

• Business Address: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
  The Bunting-Blaustein Cancer Research Building
  1650 Orleans Street, Room 443
  Baltimore, MD 21287
• Tel: 410 502-7887
• Fax: 443-287-4653

Email: poweljo@jhmi.edu

Education & Training

Professional Experience

RESEARCH ACTIVITIES

Publications: Peer-Reviewed Original Research Articles

1. Ward PA, Cunningham TW, McCullogh KK, Phan SH, Powell J, Johnson KJ. Platelet enhancement of O2- responses in stimulated human neutrophils: identification of platelet factor as an adenine nucleotide. Lab Invest. 1988; 58:37-47.
2. Powell J, Stone J, Chan WC, Yang ZD, Leatherbury A, Sell KW, Wiktor-Jedrzejczak W, Amhed-Ansari A. Interferon-gamma-treated K562 target cells distinguish functional NK cells from lymphokine-activated killer (LAK) cells. Cell Immunol. 1989; 118:250-64.
3. Powell JD, McClure HM, Anderson D, Fultz PN, Sell KW, Ahmed-Ansari A. Phenotypic and functional differences in NK and LAK cells in the peripheral blood of sooty mangabeys and rhesus macaques. Cell Immunol. 1989; 124:107-18.
4. Ahmed-Ansari A, Powell JD, Jensen PE, Jehuda-Cohen T, McClure HM, Anderson DC, Fultz PN, Sell KW. Requirements for simian immunodeficiency virus antigen-specific in vitro proliferation of T cells from infected rhesus macaques and sooty mangabeys. AIDS. 1990; 4:399-407.
5. Jehuda-Cohen T, Slade BA, Powell JD, Villinger F, De B, Folks TM, McClure HM, Sell KW, Ahmed-Ansari A. Polyclonal B-cell Activation reveals antibodies against human immunodeficiency virus type 1 (HIV-1) in HIV-1 seronegative individuals. Proc Natl Acad Sci USA. 1990; 87:3972-6.
6. Powell JD, Villinger F, Jehuda-Cohen T, Vuchetich M, McClure HM, Sell KW, Ahmed-Ansari A. Identification of SIV/SMM viral proteins that induce T cell response in experimentally infected rhesus macaques and naturally infected sooty mangabeys by the cellular western blot assay. J Med Primatol. 1990; 19:227-38.
7. Jehuda-Cohen T, Powell JD, Villinger F, McClure HM, Sell KW, Ahmed-Ansari A. Comparison of SIV/SMM replication in CD4+ T cells and monocyte/macrophage cultures from rhesus macaques and sooty mangabeys. J Med Primatol. 1990; 19:251-67.
8. Jehuda-Cohen T, Villinger F, Powell JD, McClure HM, Sell KW, Ansari AA. Presence of SIV antibodies in the sera of infants born to SIV-seronegative monkeys (letter). J Acquir Immune Defic Syndr. 1991; 4:204-5.
9. Villinger F, Powell JD, Jehuda-Cohen T, Neckelmann N, Vuchetich M, De B, Folks TM, McClure HM, Ansari AA. Detection of occult simian immunodeficiency virus SIVsmm infection in asymptomatic seronegative nonhuman primates and evidence for variation in SIV gag sequence between in vivo- and in vitro-propagated virus. J Virol.1991; 65:1855-62. PMCID: PMC239995.
10. Jehuda-Cohen T, Powell JD, Sell KW, Villinger F, Lockwood E, McClure HM, Ahmed-Ansari A. Transmission of retroviral infection by transfusion of seronegative blood in nonhuman primates. J Infect Dis. 1991; 163:1223-8.
11. Powell JD, Bednarik DP, Jehuda-Cohen T, Villinger F, Folks TM, Ansari AA. Regulation of immune activation/retroviral replication by CD8+ T cells. Ann N Y Acad Sci. 1991; 636:360-2.
12. Powell JD, Bednarik DP, Folks TM, Jehuda-Cohen T, Villinger F, Sell KW, Ansari AA. Inhibition of cellular activation of retroviral replication by CD8+ T cells derived from nonhuman primates. Clin Exp Immunol. 1993; 91:473-81.
13. Jehuda-Cohen T, Powell JD, Villinger F, Mayne AE, Sell KW, Ansari AA. Evidence for simian immunodeficiency virus-specific IgM and IgG response in peripheral blood mononuclear cells of serum enzyme-linked immunosorbent assay-negative nonhuman primates. J Acquir Immune Defic Syndr. 1994; 7:539-50.
14. Powell JD, Lerner CG, Schwartz RH. Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation. J Immunol. 1999; 162:2775-2784
15. Powell JD, Lerner CG, Ewoldt GR, Schwartz RH. The –180 site of the IL-2 promoter is the target of CREB/CREM binding in T cell anergy. J Immunol. 1999, 163:6631-6639.
16. Lerner CG, Horton MR, Schwartz RH, Powell JD. Distinct requirements for C-C chemokine and IL-2 production by naïve, previously activated and anergic T cells. J Immunol. 2000,164:3996-4002.
17. Bostik P, Mayne AF, Villenger F, Greenberg KP, Powell JD, Ansari AA. Relative resistance in the development of T cell anergy in CD4+ T cells from simian immunodeficiency virus- resistant sooty mangabeys. J Immunol. 2001, 166: 506-516
18. Powell JD, Bruniquel D, Schwartz RH. TCR engagement in the absence of cell cycle progression leads to T cell anergy independent of p27Kip1. European J. Immunol. 2001, (12) 3737-46.
19. Horton MR, Boodoo S, Powell JD. NF-kappa B activation mediates the cross-talk between extracellular matrix and interferon-gamma (IFN-gamma) leading to enhanced monokine induced by IFN-gamma (MIG) expression in macrophages. J Biol Chem. 2002 Nov 15;277(46):43757-62.
20. Shin T, Kennedy G, Gorski K, Tsuchiya H, Koseki H, Azuma M, Yagita H, Chen L, Powell J, Pardoll D, Housseau F. Cooperative B7-1/2 (CD80/CD86) and B7-DC Costimulation of CD4+ T Cells Independent of the PD-1 Receptor. J Exp Med. 2003 Jul 7;198(1):31-8. PMCID: PMC2196092.
21. Sikder H, Huso DL, Zhang H, Wang B, Ryu B, Hwang ST, Powell, JD, Alani RM. Disruption of ID1 reveals major differences in angiogenesis between transplanted and autochtonous tumors. Cancer Cell. 2003 Oct;4(4):291-9.
22. Allen A, Zheng Y, Gardner L, Safford M, Horton MR, Powell JD. The novel cyclophilin binding compound Sanglifehrin A disassociates G1 cell cycle arrest from tolerance induction. J. Immunology. 2004 172(8):4797-803
23. Powell JD, Boodoo S, Horton MR. Identification of the molecular mechanism by which TLR ligation and IFN-gamma synergize to induce MIG. Clin Dev Immunol. 2004 Mar;11(1):77-85. PMCID: PMC2275409.
24. Kowalski J, Powell J. Nonparametric inference for stochastic linear hypotheses: Application to high-dimensional data. Biometrika 2004. 91(2): 393-408.
25. Huang CT, Workman CJ, Flies D, Pan X, Marson AL, Zhou G, Hipkiss EL, Ravi S, Kowalski J, Levitsky HI, Powell JD, Pardoll DM, Drake CG, Vignali DA. Role of LAG-3 in regulatory T cells. Immunity. 2004 Oct;21(4):503-13.
26. Safford M, Collins S, Lutz MA, Allen A, Huang CT, Kowalski J, Blackford A, Horton MR, Drake C, Schwartz RH, Powell JD. Egr-2 and Egr-3 are negative regulators of T cell activation. Nature Immunology 2005 May;6(5):472-80.
27. Powell JD, Fitzhugh C, Kang EM, Hsieh M, Schwartz RH, Tisdale JF. Low-Dose Radiation Plus Rapamycin Promotes Long-Term Bone Marrow Chimerism. Transplantation. 2005 Dec 15;80(11):1541-1545.
28. Boodoo S, Spannhake EW, Powell JD, Horton MR. Differential Regulation of Hyluronan induced IL-8 and IP-10 in Airway Epithelial Cells. Am J Physiol Lung Cell Mol Physiol. 2006 Sep;291(3):L479-86.
29. Scheibner KA, Lutz MA, Boodoo S, Fenton MJ, Powell JD, Horton MR. Hylauronan Fragments act as endogenous danger signals by engaging TLR-2. J Immunology. 2006 Jul15:177(2):1272-81.
30. Collins S, Wolfraim LA, Drake CG, Horton MR, Powell JD. Cutting Edge: TCR-induced NAB2 enhances T cell function by coactivating IL-2 transcription. J Immunol. 2006 Dec 15;177(12):8301-5.
31. Durakovic N, Radojcic V, Skarica M, Bezak KB, Powell JD, Fuchs EJ, Luznik L. Factors governing the activation of adoptively transferred donor T-cells infused after allogeneic bone marrow transplantation in the mouse. Blood. 2007 May 15;109(10):4564-74. PMCID: PMC1885486.
32. Zheng Y, Collins S, Lutz MA, Allen AN, Kole TP, Zarek PE, Powell JD. A role for the mammalian target of rapamycin in regulating T cell activation versus anergy. J Immunol. 2007 Feb 15;178(4):2163-70.
33. Durakovic N, Radojcic V, Powell JD, Luznik L. Rapamycin promotes emergence of IL-10-secreting donor lymphocyte infusion-derived T cells without compromising their graft-versus-leukemia reactivity. Transplantation.2007 Mar 15;83(5):631-40.
34. Zarek PE, Huang CT, Lutz ER, Kowalski J, Horton MR, Linden J, Drake CG, Powell JD. A2A receptor signaling promotes peripheral tolerance by inducing T cell anergy and the generation of adaptive regulatory T cells. Blood. 2007 Oct 1. PMCID: PMC2200810.
35. Collins S, Lutz MA, Zarek PE, Anders RA, Kersh GJ, Powell JD. Opposing regulation of T cell function by Egr-1/NAB2 and Egr-2/Egr-3. Eur J Immunol. 2008 Jan 17;38(2):528-536. NIHMS: 448291.
36. Huang GN, Huso DL, Bouyain S, Tu J, McCorkell KA, May MJ, Zhu Y, Lutz M, Collins S, Dehoff M, Kang S, Whartenby K, Powell J, Leahy D, Worley PF. NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins. Science. 2008 Jan 25;319(5862):476-81. NIHMS: 448296.
37. Luznik L, O'Donnell PV, Symons HJ, Chen AR, Leffell MS, Zahurak M, Gooley TA, Piantadosi S, Kaup M, Ambinder RF, Huff CA, Matsui W, Bolaños-Meade J, Borrello I, Powell JD, Harrington E, Warnock S, Flowers M, Brodsky RA, Sandmaier BM, Storb RF, Jones RJ, Fuchs EJ. HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation cyclophosphamide. Biol Blood Marrow Transplant. 2008 Jun;14(6):641-50. PMCID: PMC2633246.
38. Scheibner KA, Boodoo S, Collins S, Black KE, Chan-Li Y, Zarek P, Powell JD, Horton MR. The Adenosine A2a Receptor Inhibits Matrix Induced Inflammation in a Novel Fashion. Am J Respir Cell Mol Biol. 2008 Aug 14. PMCID: PMC2645524.
39. Eberlein M, Scheibner KA, Black KE, Collins SL, Chan-Li Y, Powell JD, Horton MR. Anti-oxidant inhibition of hyaluronan fragment-induced inflammatory gene expression J Inflamm (Lond). 2008 Nov 5;5:20. PMCID: PMC2627834.
40. Bolaños-Meade J, Luznik L, Muth M, Matsui WH, Huff CA, Smith BD, Levy MY, Kasamon YL, Swinnen LJ, Powell JD, Brodsky RA, Ambinder RF, Jones RJ, Fuchs EJ. Salvage transplantation for allograft failure using fludarabine and alemtuzumab as conditioning regimen. Bone Marrow Transplant. 2009 Mar;43(6):477-80. PMCID: PMC2950942.
41. Delgoffe GM, Kole TP, Zheng Y, Zarek PE, Matthews KL, Xiao B, Worley PF, Kozma SC, Powell JD. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity. 2009 Jun 19;30(6):832-44 PMCID: PMC2768135.
42. Delgoffe GM, Kole TP, Cotter RJ, Powell JD. Enhanced interaction between Hsp90 and raptor regulates mTOR signaling upon T cell activation. Molecular Immunology. 2009 Aug;46(13):2694-8. Epub 2009 Jul 7. PMCID: PMC2768125.
43. Gamper CJ, Agoston AT, Nelson WG, Powell JD. Identification of DNA Methyltransferase 3a as a T cell Receptor-induced regulator of Th1 and Th2 differentiation. Journal of Immunology. 2009 Aug 15;183(4):2267-76. Epub 2009 Jul 22. PMCID: PMC2818975.
44. Kasamon YL, Jones RJ, Brodsky RA, Fuchs EJ, Matsui W, Luznik L, Powell JD, Blackford AL, Goodrich A, Gocke CD, Abrams RA, Ambinder RF, Flinn IW. Immunologic recovery following autologous stem-cell transplantation with pre- and posttransplantation rituximab for low-grade or mantle cell lymphoma. Ann Oncol. 2010 Jun;21(6):1203-10. Epub 2009 Oct 30. PMCID: PMC2875548.
45. Zheng Y, Delgoffe GM, Meyer CF, Chan W, Powell JD. Anergic T cells are metabolically anergic. J Immunol. 2009 Nov 15;183(10):6095-101. Epub 2009 Oct 19. PMCID: PMC2884282.
46. Kasamon YL, Luznik L, Leffell MS, Kowalski J, Tsai HL, Bolaños-Meade J, Morris LE, Crilley PA, O'Donnell PV, Rossiter N, Huff CA, Brodsky RA, Matsui WH, Swinnen LJ, Borrello I, Powell JD, Ambinder RF, Jones RJ, Fuchs EJ. Nonmyeloablative HLA-Haploidentical BMT with High-Dose Posttransplantation Cyclophosphamide: Effect of HLA Disparity on Outcome. Biol Blood Marrow Transplant. 2010 Apr;16(4):482-9. PMCID: PMC2998606.
47. Hsieh MM, Kang EM, Fitzhugh CD, Link MB, Bolan CD, Kurlander R, Childs RW, Rodgers GP, Powell JD, Tisdale JF. Allogeneic hematopoietic stem-cell transplantation for sickle cell disease. NEJM. 2009 Dec 10;361(24):2309-17. NIHMS: 448294.
48. Gulen MF, Kang Z, Bulek K, Youzhong W, Kim TW, Chen Y, Altuntas CZ, Bak-Jenson K, McGeachy MJ, Do JS, Xiao H, Delgoffe GM, Min B, Powell JD, Tuohy VK, Cua DJ, Li X. The Receptor SIGIRR Suppresses Th17 Cell Proliferation via Inhibition of the Interleukin-1 Receptor Pathway and mTOR Kinase Activation. Immunity. 2010 Jan 29;32(1):54-66. PMCID: PMC3015141.
49. Luznik L, Bolaños-Meade J, Zahurak M, Chen AR, Smith BD, Brodsky R, Huff CA, Borrello I, Matsui W, Powell JD, Kasamon Y, Goodman SN, Hess A, Levitsky HI, Ambinder RF, Jones RJ, Fuchs EJ. High-dose cyclophosphamide as single agent, short-course prophylaxis of graft-versus-host disease. Blood. 2010 Apr 22;115(16):3224-30. PMCID: PMC2858487.
50. Kasamon YL, Luznik L, Leffell MS, Kowalski J, Tsai HL, Bolaños-Meade J, Morris LE, Crilley PA, O'Donnell PV, Rossiter N, Huff CA, Brodsky RA, Matsui WH, Swinnen LJ, Borrello I, Powell JD, Ambinder RF, Jones RJ, Fuchs EJ. Nonmyeloablative HLA-haploidentical bone marrow transplantation with high-dose posttransplantation cyclophosphamide: effect of HLA disparity on outcome. Biol Blood Marrow Transplant. 2010 Apr;16(4):482-9. PMCID: PMC2998606.
51. Akbulut S, Reddi AL, Aggarwal P, Ambardekar C, Canciani B, Kim MK, Hix L, Vilimas T, Mason J, Basson MA, Lovatt M, Powell J, Collins S, Quatela S, Phillips M, Licht JD. Sprouty proteins inhibit receptor-mediated activation of phosphatidylinositol-specific phospholipase C. Mol Biol Cell. 2010 Oct;21(19):3487-96. PMCID: PMC2947483.
52. Collins SL, Black KE, Chan-Li Y, Ahn YH, Cole PA, Powell JD, Horton MR. Hyaluronan Fragments Promote Inflammation by Down-Regulating the Anti-Inflammatory A2a Receptor. Am J Respir Cell Mol Biol. 2011 Jan 21. [Epub ahead of print] PMCID: PMC3208614.
53. Delgoffe GM, Pollizzi KN, Waickman AT, Heikamp E, Meyers DJ, Horton MR, Xiao B, Worley PF, Powell JD. The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat Immunol. 2011 Apr;12(4):295-303. PMCID: PMC3077821.
54. Michalek RD, Gerriets VA, Nichols AG, Inoue M, Kazmin D, Chang CY, Dwyer MA, Nelson ER, Pollizzi KN, Ilkayeva O, Giguere V, Zuercher WJ, Powell JD, Shinohara ML, McDonnell DP, Rathmell JC. Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation. Proc Natl Acad Sci US A. 2011 Nov 8;108(45):18348-53. Epub 2011 Oct 31. PMCID: PMC3215012.
55. Waickman AT, Alme A, Senaldi L, Zarek PE, Horton M, Powell JD. Enhancement of tumor immunotherapy by deletion of the A(2A) adenosine receptor. Cancer Immunol Immunother. 2011 Nov 25. [Epub ahead of print] NIHMS: 448300.
56. Ghosh S, Lau H, Simons BW, Powell JD, Meyers DJ, De Marzo AM, Berman DM, Lotan TL. PI3K/mTOR signaling regulates prostatic branching morphogenesis. Dev Biol. 2011 Dec 15;360(2):329-42. Epub 2011 Oct 8. PMCID: PMC3225010
57. Li Q, Rao RR, Araki K, Pollizzi K, Odunsi K, Powell JD, Shrikant PA. A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity. Immunity. 2011 Apr 22;34(4):541-53. PMCID: PMC3083826.
58. Gladstone DE, Bolaños-Meade J, Huff CA, Zahurak M, Flinn I, Borrello I, Luznik L, Fuchs E, Kasamon Y, Matsui W, Powell J, Levitsky H, Brodsky RA, Ambinder R, Jones RJ, Swinnen LJ. High-dose cyclophosphamide and rituximab without stem cell transplant: a feasibility study for low grade B-cell, transformed and mantle cell lymphomas. Leuk Lymphoma. 2011 Nov;52(11):2076-81. Epub 2011 Jul 14. PMCID: PMC3390263.
59. Collins SL, Chan-Li Y, Hallowell RW, Powell JD, Horton MR. Pulmonary vaccination as a novel treatment for lung fibrosis. PLoS One. Epub 2012 Feb 17;7(2):e31299. PMCID: 3281950.
60. Thomas RM, Gamper CJ, Ladle BH, Powell JD, Wells AD. De novo DNA methylation is required to restrict T helper lineage plasticity. J Biol Chem. 2012 May 14. [Epub ahead of print]. PMCID: PMC3391093.
61. Collins S, Waickman A, Basson A, Kupfer A, Licht JD, Horton MR, Powell JD. Regulation of CD4⁺ and CD8⁺ effector responses by Sprouty-1. PloS One. 2012 ;7(11):e49801. PMCID: PMC3499516.
62. Thornton KA, Chen AR, Trucco MM, Shah P, Wilky BA, Gul N, Carrera-Haro MA, Ferreira MF, Shafique U, Powell JD, Meyer CF, Loeb DM. A dose finding study of temsirolimus and liposomal doxorubicin for patients with recurrent and refractory bone and soft tissue sarcoma. Int J Cancer. 2013 Feb 5. doi: 10.1002/ijc.28083. [Epub ahead of print] PMCID Requested.
63. Black KE, Collins SL, Hagan RS, Hamblin MJ, Chan-Li Y, Hallowell RW, Powell JD, Horton MR. Hyaluronan fragments induce IFNbeta via a novel TLR4-TRIF-TBK1-IRF3-dependent pathway. J Inflamm (Lond). 2013 May 30;10(1):23. [Epub ahead of print] PubMed PMID: 23721397.
64. Kim JS, Sklarz T, Banks LB, Gohil M, Waickman AT, Skuli N, Krock BL, Luo CT, Hu W, Pollizzi KN, Li MO, Rathmell JC, Birnbaum MJ, Powell JD, Jordan MS, Koretzky GA. Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways. Nat Immunol. 2013 Jun;14(6):611-8. doi: 10.1038/ni.2607. Epub 2013 May 5. PubMed PMID: 23644504.
65. Fitzhugh CD, Weitzel RP, Hsieh MM, Phang OA, Madison C, Luznik L, Powell JD, Tisdale JF. Sirolimus and post transplant Cy synergistically maintain mixed chimerism in a mismatched murine model. Bone Marrow Transplant. 2013 Apr 22. doi:10.1038/bmt.2013.60. [Epub ahead of print] PubMed PMID: 23604009.
66. Lo YC, Edidin MA, Powell JD. Selective activation of antigen-experienced T cells by anti-CD3 constrained on nanoparticles. J Immunol. 2013 Nov 15;191(10):5107-14. doi: 10.4049/jimmunol.1301433. Epub 2013 Oct 4. PubMed PMID: 24098054; PubMed Central PMCID: PMC3831631.
67. Powell JD, Heikamp EB, Pollizzi KN, Waickman AT. A Modified Model of T-Cell Differentiation Based on mTOR Activity and Metabolism. Cold Spring Harb Symp Quant Biol. 2013 Oct 7. [Epub ahead of print] PubMed PMID: 24100582.
68. Chiu YL, Shan L, Huang H, Haupt C, Bessell C, Canaday DH, Zhang H, Ho YC, Powell JD , Oelke M, Margolick JB, Blankson JN, Griffin DE, Schneck JP. Sprouty-2 regulates HIV-specific T cell polyfunctionality. J Clin Invest. 2013 Dec 2. pii: 70510. doi: 10.1172/JCI70510. [Epub ahead of print] PubMed PMID: 24292711.
69. Chiang MJ, Holbert MA, Kalin JH, Ahn YH, Giddens J, Amin MN, Taylor MS, Collins SL, Chan-Li Y Waickman A, Hsiao PY, Bolduc D, Leahy DJ, Horton MR, Wang LX, Powell JD, Cole PA. An fc domain protein-small molecule conjugate as an enhanced immunomodulator. J Am Chem Soc. 2014 Mar 5;136(9):3370-3.
70. Emily B. Heikamp1¬¬, Chirag H. Patel1, Sam Collins2, Adam Waickman1, Min-Hee Oh2, Im-Hong Sun1, Peter Illei3, Archna Sharma4, Aniko Naray-Fejes-Toth5, Geza Fejes-Toth5, Jyoti Sen4, Maureen Horton2, and Jonathan D. Powell1,6. The AGC kinase serum- and glucocorticoid-regulated kinase 1 (SGK1) regulates Th1

Invited Review Articles

1. Powell JD & Horton MR. Immunol. Res. Threat Matrix: Low Molecular Weight Hyaluronan (HA) as a Danger Signal. Immunol Res. 2005;31(3):207-18.
2. Powell JD. The induction and Maintenance of T cell Anergy. Clin Immunol. 2006 Sep;120(3):239-46.
3. Powell JD, Zheng Y. Dissecting the mechanism of T-cell anergy with immunophilin ligands. Curr Opin Investig Drugs. 2006 Nov;7(11):1002-7. Review.
4. Zarek P.E., Powell J.D. Adenosine and anergy. Autoimmunity.2007 Sep;40(6):425-32.
5. Delgoffe GM, Powell JD. Immunology. 2009 Aug;127(4):459-65. mTOR: taking cues from the immune microenvironment. PMCID: PMC2729523.
6. Gamper CJ, Powell JD. Genetic and biochemical regulation of CD4 T cell effector differentiation: insights from examination of T cell clonal anergy. Immunol Res. 2010 Jul;47(1-3):162-71. PMCID: PMC2892254.
7. Powell JD, Delgoffe GM. The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism. Immunity. 2010 Sep 24;33(3):301-11. PMCID: PMC2962404.
8. Powell JD, Pollizzi KN, Heikamp EB, Horton MR. Regulation of immune responses by mTOR. Annu Rev Immunol. 2012 [Epub 2011 Nov 29];30:39-68. NIHMS: 448316.
9. Waickman AT, Powell JD. Mammalian target of rapamycin integrates diverse inputs to guide the outcome of antigen recognition in T cells. J Immunol. 2012 May 15;188(10):4721-9. PMCID: 3347776.
10. Waickman AT, Powell JD. mTOR, metabolism, and the regulation of T-cell differentiation and function. Immunol Rev. 2012 Sep; 249(1):43-58. PMCID: PMC3419491.
11. Gamper CJ, Powell JD. All PI3Kinase signaling is not mTOR: dissecting mTOR-dependent and independent signaling pathways in T cells. Front. Immunol. 2012 ;3:312. PMCID: PMC3466461.
12. Heikamp EB, Powell JD. Sensing the immune microenvironment to coordinate T cell metabolism, differentiation & function. Semin Immunol. 2013 Jan 14. pii: S1044-5323(12)00108-X. PMCID Requested.
13. Lo YC, Lee CF, Powell JD. Insight into the role of mTOR and metabolism in T cells reveals new potential approaches to preventing graft rejection. Curr Opin Organ Transplant. 2014 Aug;19(4):363-71 PMCID Requested.

Editorials

1. Powell JD, INSIDE BLOOD: Bringing IL-2 down to earth Blood April 1, 2007 109:2671-2672; doi:10.1182/blood-2007-01-067017
2. Horton MR, Powell JD. Quieting T cells with Slfn2. Nat Immunol. 2010 Apr;11(4):281-2. Review. NIHMS: 448320.
3. Hagan RS, Powell JD. Targeted immunosuppression: No longer naïve. Clin Immunol. 2011 Oct 25. [Epub ahead of print] NIHMS: 448335.
4. Powell JD, Pollizzi K. Fueling memories. Immunity. 2012 Jan 27;36(1):3-5 PMCID: PMC3273990.
5. Powell JD. Slc7a5 helps T cells get with the program. Nat Immunol. 2013 May;14(5):422-4. doi: 10.1038/ni.2594. PubMed PMID: 23598390.

Editorials

1. Powell JD, McClure HM, Ahmed-Ansari A. Primate immunology, a review. In: Traite d'immunologie animale. Paris: Flammarion Press, Inc., 1989:471-92.
2. Powell JD & Schwartz RH. Shifting Paradigms in Peripheral Tolerance. In Burt RK & Marmont A eds. Stem Cell Therapy for Autoimmune Disease 2003:132-139.
3. Cooper M, Caligiuri, MA, Max EE, Powell J, Lymphocyte Biology. In Clinical Hematology, Young, NS, Gerson Sl, High KA Editors. Elsevier Press 2006: 71-89.
4. Fishman P, Bar-Yehuda S, Synowitz M, Powell JD, Klotz KN, Gessi S, Borea PA. Adenosine receptors and cancer. Handb Exp Pharmacol. 2009;(193):399-441. NIHMS: 448362.
5. Delgoffe GM, Powell JD. Exploring functional in vivo consequences of the selective genetic ablation of mTOR signaling in T helper lymphocytes. Methods Mol Biol. 2012;821:317-27. PMCID: PMC3571700.