Vineet N. KewalRamani
HIV Drug Resistance Program
Senior Investigator, National Cancer Institute
Get in Touch
Email: vineet.kewalramani@nih.gov
Education
1989 B.S.
University of Wisconsin, Madison, Wisconsin.
Molecular Biology & Zoology
Molecular Biology & Zoology
1996 Ph.D.
University of Washington, Seattle, Washington
Microbiology
Microbiology
1999 Postdoctoral.
Skirball Institute, NYU Medical Center, NY, NY
Immunology & Virology
Immunology & Virology
Crossed Appointments
1990-1996
Graduate research in the laboratory of Michael Emerman, Fred Hutchinson Cancer Research Center, Seattle, Washington
1996-1999
Postdoctoral research in the laboratory of Dan R. Littman, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, New York
1999-present
Head, Model Development Section (tenured to Senior Investigator in 2010), HIV Drug Resistance Program, National Cancer Institute, Frederick National Laboratory
2004-2011
NIH Foundation Norman P. Salzman Award Committee
2006.
NIH Salzman Virology Scientific Committee Co-Chair
2007.
NIH Salzman Virology Scientific Committee Chair
2008-2010
U.S. Government Microbicides Working Group (USMWG)
2010.
Member, NIH Earl Stadtman Immunology Search Committee
2011-2012
Chair, NIH Earl Stadtman Virology Search Committee
2012.
Co-Organizer, Cold Spring Harbor Laboratory Retroviruses Meeting
Scientific Advisory Boards or Review Panels
2002-2005
Glaser Pediatric AIDS Foundation Scholar and Basic Research Grant
2005-2012
American Foundation for AIDS Research, Basic Sciences Review Panel
2007-2011
University of Pittsburgh Center for HIV Protein Interactions P50 Scientific Advisory Board
Honors and Awards
1996
Howard Hughes Medical Institute Postdoctoral Fellowship
1996-1999.
Damon Runyon-Walter Winchell Postdoctoral Fellowship
1994
Helen R. Whiteley Graduate Fellowship
2007
NCI Federal Technology Transfer Award
2012
NIH Director’s Award Editorial boards (Virology 2003-present, Retrovirology 2004-2006, PLoS One 2006-present, Journal of Virology 2007-2009)
2007-2008.
NIH Intramural AIDS Targeted Antiviral Program Research Award
2010
Center for Cancer Research/Office of AIDS Research Multi-Investigator Award
Publications
- KewalRamani, V.N., and M. Emerman. 1996. Vpx association with mature core structures of HIV-2.Virology 218:159-168.
- KewalRamani, V.N., C.S. Park, P.A. Gallombardo, and M. Emerman. 1996. Protein stability influences human immunodeficiency virus type 2 Vpr virion incorporation and cell cycle effect. Virology 218:326-334.
- Deng, H-K., D. Unutmaz, V.N. KewalRamani, and D.R. Littman. 1997. Expression cloning of novel coreceptors used by simian and human immunodeficiency viruses. Nature 388:296-300.
- Unutmaz D., V.N. KewalRamani, S. Marmon, and D.R. Littman. 1999. Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes. J. Exp. Med. 189:1735-1746.
- Geijtenbeek, T.B., D.S. Kwon, R. Torensma, S.J. van Vliet, G.C. van Duijnhoven, J. Middel, I.L. Cornelissen, H.S. Nottet, V.N. KewalRamani, D.R. Littman, C.G. Figdor, and Y. van Kooyk. 2000. DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Cell 100:587-597.
- Wu, L., A.A. Bashirova, T.D. Martin, L. Villamide, E. Mehlhop, A.O. Chertov, D. Unutmaz, M. Pope, M. Carrington, and V.N. KewalRamani. 2002. Rhesus macaque dendritic cells efficiently transmit primate lentiviruses independently of DC-SIGN. Proc. Natl. Acad. Sci. USA 99:1568-1573.
- Baumann, J.G., D. Unutmaz, M.D. Miller, S.K.J. Breun, S.M. Grill, J. Mirro, D.R. Littman, A. Rein, and V.N. KewalRamani. 2004. Murine T cells potently restrict human immunodeficiency virus infection. J. Virol.78:12537-12547.
- Mulky, A., T.V. Cohen, S.V. Kozlov, R. Foisner, C.L. Stewart*, and V.N. KewalRamani*. 2008. The LEM domain proteins emerin and LAP2α are dispensable for human immunodeficiency virus type 1 and murine leukemia virus infections. J. Virol. 82:5860-5868. *co-corresponding authors
- Ambrose Z, Compton L, Piatak M, Lu D, Alvord WG, Lubomirski MS, Hildreth JE, Lifson JD, Miller CJ, KewalRamani VN. Incomplete protection against simian immunodeficiency virus vaginal transmission in rhesus macaques by a topical antiviral agent revealed by repeat challenges. J. Virol. 82: 6591-9, 2008.
- Shao W, Kearney M, Maldarelli F, Mellors JW, Stephens RM, Lifson JD, KewalRamani VN, Ambrose Z, Coffin JM, Palmer SE. RT-SHIV subpopulation dynamics in infected macaques during anti-HIV therapy. Retrovirology. 6: 101, 2009.
- Hatziioannou T, Ambrose Z, Chung NP, Piatak M, Yuan F, Trubey CM, Coalter V, Kiser R, Schneider D, Smedley J, Pung R, Gathuka M, Estes JD, Veazey RS, KewalRamani VN, Lifson JD, Bieniasz PD. A macaque model of HIV-1 infection. Proc. Natl. Acad. Sci. U.S.A. 106: 4425-9, 2009.
- Michel N, Goffinet C, Ganter K, Allespach I, Kewalramani VN, Saifuddin M, Littman DR, Greene WC, Goldsmith MA, Keppler OT. Human cyclin T1 expression ameliorates a T-cell-specific transcriptional limitation for HIV in transgenic rats, but is not sufficient for a spreading infection of prototypic R5 HIV-1 strains ex vivo. Retrovirology. 6: 2, 2009.
- Furtak V, Mulky A, Rawlings SA, Kozhaya L, Lee K, Kewalramani VN, Unutmaz D. Perturbation of the P-Body Component Mov10 Inhibits HIV-1 Infectivity. PLoS ONE. 5: e9081, 2010.
- Krishnan, L., K. Matreyek, I. Oztop, K. Lee, C.H. Tipper, X. Li, M.J. Dar, V.N. KewalRamani*, and A. Engelman*. 2010. The requirement for cellular transportin-3 (TNPO3/TRN-SR2) during infection maps to human immunodeficiency virus type 1 capsid and not integrase. J. Virol. 84:397-406. *equal contributors
- Chung, N.P.Y., S.K.J. Breun, A. Bashirova, J.G. Baumann, T.D. Martin, J.M. Karamchandani, J.W. Rausch, S.F.J. Le Grice, L. Wu, M. Carrington, and V.N. KewalRamani. 2010. HIV-1 transmission by DC-SIGN is regulated by determinants in the carbohydrate recognition domain that are absent in L-SIGN. J. Biol. Chem. 285: 2100-2112.
- Lee, K., Z. Ambrose, T.D. Martin, I. Oztop, A. Mulky, J.G. Julias, N. Vandegraaff, J.G. Baumann, R. Wang, W. Yuen, T. Takemura, K. Shelton, I. Taniuchi, Y. Li, J. Sodroski, D.R. Littman, J.M. Coffin, S.H. Hughes, D. Unutmaz, A. Engelman, and V.N. KewalRamani. 2010. Flexible use of nuclear import pathways by HIV-1. Cell Host Microbe 7:221-233
- Schaller, T., K.E. Ocwieja, J. Rasaiyaah, A.J. Price, T.L. Brady, S.L. Roth, S. Hué, A.J. Fletcher, K. Lee, V.N. KewalRamani, M. Noursadeghi, R.G. Jenner, L.C. James, F.D. Bushman, and G.J. Towers. 2011. HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency. PLoS Pathog. 7(12):e1002439.
- Kearney M, Spindler J, Shao W, Maldarelli F, Palmer S, Hu SL, Lifson JD, Kewalramani VN, Mellors JW, Coffin JM, Ambrose Z. Genetic Diversity of Simian Immunodeficiency Virus Encoding HIV-1 Reverse Transcriptase Persists in Macaques despite Antiretroviral Therapy. J. Virol. 85: 1067-76, 2011.
- Schaller T, Ocwieja KE, Rasaiyaah J, Price AJ, Brady TL, Roth SL, Hué S, Fletcher AJ, Lee K, Kewalramani VN, Noursadeghi M, Jenner RG, James LC, Bushman FD, Towers GJ. HIV-1 Capsid-Cyclophilin Interactions Determine Nuclear Import Pathway, Integration Targeting and Replication Efficiency. PLoS Pathog. 7: e1002439, 2011.
- Boltz VF, Ambrose Z, Kearney MF, Shao W, Kewalramani VN, Maldarelli F, Mellors JW, Coffin JM. Ultrasensitive allele-specific PCR reveals rare preexisting drug-resistant variants and a large replicating virus population in macaques infected with a simian immunodeficiency virus containing human immunodeficiency virus reverse transcriptase. J. Virol. 86: 12525-30, 2012.
- Lee, K., A. Mulky, W. Yuen, T.D. Martin, N.R. Meyerson, L. Choi, H. Yu, S.L. Sawyer, and V.N. KewalRamani. 2012. HIV-1 capsid-targeting domain of cleavage and polyadenylation specificity factor 6. J. Virol. 86: 3851-3860.
- Ambrose, Z., K. Lee, J. Ndjomou, H. Xu, I. Oztop, J. Matous, T. Takemura, D. Unutmaz, A. Engelman, S.H. Hughes, and V.N. KewalRamani. 2012. Human immunodeficiency virus type 1 capsid mutation N74D alters cyclophilin A dependence and impairs macrophage infection. J. Virol. 86: 4708-4714.
- Price, A.J., A.J. Fletcher, T. Schaller, T. Elliott, K. Lee, V.N. KewalRamani, J.W. Chin, G.J. Towers, and L.C. James. 2012. CPSF6 defines a conserved capsid interface that modulates HIV-1 replication. PLoS Pathog. 8(8): e1002896.
- Maertens GN, Cook NJ, Wang W, Hare S, Gupta SS, Oztop I, Lee K, Pye VE, Cosnefroy O, Snijders AP, Kewalramani VN, Fassati A, Engelman A, Cherepanov P. Structural basis for nuclear import of splicing factors by human Transportin 3. Proc. Natl. Acad. Sci. U.S.A. 111: 2728-33, 2014.
- Koh Y, Wu X, Ferris AL, Matreyek KA, Smith SJ, Lee K, Kewalramani VN, Hughes SH, Engelman A. Differential Effects of Human Immunodeficiency Virus Type 1 Capsid and Cellular Factors Nucleoporin 153 and LEDGF/p75 on the Efficiency and Specificity of Viral DNA Integration. J. Virol. 87: 648-58, 2013.
