【學會理監事】

1.台灣預防醫學學會理事(現任)

2.台灣生物安全協會理事(現任)

3.中華民國哈佛大學同學會理事(現任)

4.台灣卡羅歐巴尼協會理事(現任)

【學術期刊審查】

1.應邀擔任國外著名學術期刊(EmergingInfectiousDisease)之論文審

查委員(現任)

2.應邀擔任國外著名學術期刊(Parasites&Vectors)之論文審查委員(現

任)

3.應邀擔任國外著名學術期刊(TicksandTick-Borne Diseases)之論文

審查委員(現任)

4.應邀擔任國外著名學術期刊(AfricanJournal of Microbiology

Research)之論文審查委員(現任)

5.應邀擔任國內著名學術期刊（Journalof Microbiology,Immunology

andInfection）之編審委員(AssociateEditor)(現任)

6.應邀擔任國內著名學術期刊（FormosanEntomologist）之編審委員

(EditorialBoard)(現任)

7.應邀擔任國內著名學術期刊（KaohsiungJournalof MedicalSciences）

之論文審查委員(現任)

8.應邀擔任國外著名學術期刊(Journalof MedicalEntomology)之論文

審查委員(現任)

【研究專長】

1	熱帶醫學	4	分子診斷技術
2	人畜共通傳染病學	5	病媒管制
3	醫用寄生蟲學	6	醫用微生物學(細菌學)

【研究成果及未來研究方向概要】

             本人之研究重點乃專注於蜱媒介人畜共通傳染病(tickborne zoonoses)之相關研究，近年來之研究成果不但驗證台灣地區首例萊姆病(Lyme disease)及巴貝氏原蟲症(Babesiosis)之臨床病例，亦首次自台灣鼠類宿主組 織中分離及純種培養出萊姆病致病疏螺旋體(Borrelia burgdorferi)，並進一 步分析台灣分離菌株(Twkm1-7)之蛋白組成、免疫抗原成份及其基因種株(genospecies)等基本特性，亦創造了亞洲地區首次基因種株(B.burgdorferi sensu stricto)之發表，並因而建立國內唯一之萊姆病感染診斷標準實驗室。目前成果除了證實萊姆病致病疏螺旋體(B. burgdorferi)存在於台灣粒形硬蜱(Ixodes granulatus)之事實，並首次自人體皮膚組織分離培養出多種基因 種株之致病疏螺旋體(B.burgdorferi sensu stricto, B. garinii, and B. afzelii)，因而驗證台灣地區萊姆病致病疏螺旋體之基因多樣性(genetic diversity)。未來研究方向將著重在「蜱媒介人畜共通病原體之感染診斷試劑研發」、「台灣地區蜱媒介人畜共通病原體之分子鑑定分析」、「台灣地區蜱媒介人畜共 通病原體之分子流行病學」、「台灣地區蜱種之親緣演化及族群遺傳分析」及「台灣地區萊姆病感染與非何杰金氏淋巴瘤關聯性之探討」等相關基礎及臨床診斷研究。

【近年發表之論文著作】

   1.Chao LL, Yu WC, Chang MT, and Shih CM* (2014). Reservoir host for Babesia infection on the offshore Kinmen Island of              Taiwan.Asian Pacific Journal of Tropical Medicine, Accepted, (Corresponding author) (SCI in Tropical Medicine)

 2.Chao LL, Lu CF, and Shih CM* (2013). Molecular detection and genetic identification of Borrelia garinii and Borrelia afzelii from patients presenting with a rare skin manifestation of prurigo pigmentosa in Taiwan. International Journal of Infectious Diseases 17(12):e1141-e1147. (Corresponding author) (SCI in Infectious Disease)

 3.Chao LL, Hsieh CK, and Shih CM* (2013). First report of Amblyomma helvolum (Acari: Ixodidae) from the Taiwan stink snake,Elaphe carinata(Reptilia: Colubridae), collected in southern Taiwan. Ticks and Tick-Borne Diseases 4:246-250. (Corresponding author)(SCI in Parasitology)

 4.Hu JM, Wang CC, Chao LL, Lee CS, and Shih CM* (2013). First report of furuncular

myiasiscaused by the larva of botfly, Dermatobia hominis,in a Taiwanese traveler.

sian PacificJournal of Tropical Biomedicine 3(3):229-231. (Corresponding author)

 5.Chao LL, Liu LL, and Shih CM* (2012). Prevalence and molecular identification of Borrelia spirochetes in Ixodes granulatus ticks collected from Rattus losea on Kinmen Island of Taiwan. Parasites & Vectors 5:167. (Corresponding author) (SCI in Parasitology).

 6.Chao LL and Shih CM* (2012). First report of human biting activity of Ixodes acutitarsus (Acari:Ixodidae) collected in Taiwan.Experimental and Applied Acarology 56:159-164.(Corresponding author) (SCI in Entomology).

 7.Chao LL, Wu WJ, and Shih CM* (2011). Species identification of Ixodes granulatus based on the ribosomal DNA spacer, internal transcribed spacer 2 (ITS-2), sequences. Experimental and Applied Acarology 54:51-63. (Corresponding author) (SCI in Entomology).

 8.Chao LL, Chen YJ, and Shih CM* (2011). First isolation and molecular identification ofBorrelia burgdorferi sensu stricto and B. afzelii from skin biopsies of patients in Taiwan. International Journal of Infectious Diseases 15:e182-e187. (Corresponding author) (SCI in Infectious Disease). 

 9.Chao LL, Wu WJ, and Shih CM* (2010). Molecular detection of Borrelia valaisiana-related spirochetes from Ixodes granulatus ticks in Taiwan. Experimental and Applied Acarology 52:393-407. (Corresponding author) (SCI in Entomology)

 10.Chang BL, Shih CM, Ro LS, Huang CC, Lyu RK, Chen RS, Lee JD, Chao LL, Kuo HC (2010). Acute neuroborreliosis with involvement of the central nervous system. Journal of the Neurological Sciences 295:10-15. (SCI in Neurological Sciences)

  11.Chao LL, Chen YJ, and Shih CM* (2010). First detection and molecular identification ofBorrelia garinii isolated from human skin in Taiwan. Journal of MedicalMicrobiology59(2):254-257. (Corresponding author) (SCI in Microbiology)

12.Huang GS, Shih CM, Wu CC, Hu MH, Tsai CS, Liaw WJ, Chan SM, and Li CY (2010).Hypertonic saline, mannitol and hydroxyethyl starch preconditioning of plateletsobtained from septic patients attenuates CD40 ligand expression in vitro. The Journal of Trauma, Injury, Infection and Critical Care 68:331-336. (SCI in Emergency Medicine)

13.Chao LL and Shih CM* (2009). Genetic analysis of the flagellin gene of Lyme diseasespirochetes (Borrelia burgdorferi) isolated from rodents in Taiwan. Journal of MedicalSciences 29(5): 249-255. (Corresponding author)

14.Dai NT, Yeh MK, Chiang CH, Chen KC, Liu TH, Feng AC, Chao LL, Shih CM, Sytwu HK, Chen TM, and Adams EF (2009). Human single-donor composite skin substitutes based on collagen and polycaprolactone copolymer. Biochemical and Biophysical Research Communications 386: 21-25. (SCI in Biophysics)

  15.Chao LL, Wu WJ, and Shih CM* (2009). First detection and molecular identification of Borrelia burgdorferi-like spirochetes in Ixodes granulatus ticks collected on Kinmen island of Taiwan. American Journal of Tropical Medicine and Hygiene 80(3):389-394.(Corresponding author) (SCI in Tropical Medicine)

16.Chao LL, Wu WJ, and Shih CM* (2009). Molecular analysis of Ixodes granulatus, a possible vector tick for Borrelia burgdorferi sensu lato in Taiwan. Experimental and Applied Acarology 48:329-344,(Corresponding author) (SCI in Entomology)

  17.Hsieh YF, Liu HW, Hsu TC, Wei JCC, Shih CM, Peter J Krause, and Gregory J Tsay (2007). Serum reactivity against Borrelia burgdorferi OspA in patients with rheumatoid arthritis. Clinical and Vaccine Immunology 14(11):1437-1441.(SCI in Immunology)

  18.Li TH, Shih CM, Lin WJ, Lu CW, Chao LL, and Wang CC (2007). Erythema migrans mimicking cervical cellulitis with deep neck infection in a child with Lyme disease.Journal of the Formosan Medical Association 106(7):577-581. (SCI in Medicine; 國科會優良期刊)

  19.Dai NT, Yeh MK, Liu DD, Adams EF, Chiang CH, Yen CY, Shih CM, Sytwu HK, Chen TM, Wang HJ, Williamson MR, and Coombes AGA (2005). A co-cultured skin model based on cell support membranes. Biochemical Biophysical Research Communications329:905-908. (SCI in Biophysics)

  20.Tsai CS, Hsu PC, Huang GS, Lin TC, Hong GJ, Shih CM, and Li CY (2004). Midazolam attenuates adenosine diphosphate-induced P-selectin expression and platelet-leukocyte aggregation. European Journal of Anaesthesiology 21:871-876. (SCI in Anaesthesiology).

  21.Shih CM* and Chao LL (2004). Current status of Lyme disease in Taiwan with description of its vector ticks and  reservoir hosts. Proceedings of the Symposium on Rodent Damage and Control Strategy; pp. 79-92, The Plant Protection  Society of the Republic of China, Taichung, Taiwan, Republic of China.

  22.Chen HC, Shih CM, Lai JH, Chao LL, Kuo SY and Chang DM (2004). Pleural effusion as a manifestation of Lyme disease: a  case report. Journal of Rheumatology  31:811-813.(SCI in Rheumatology).

  23.羅文聰、王志堅、師健民  (2003). 認識萊姆病。感染控制雜誌，13 卷，第 113-118頁。

 24.Shih CM* (2002). Current status of tick-borne zoonotic Lyme disease in Taiwan.Symposium on zoonotic infections; pp.17-    27,Bureau of Animal and Plant Health Inspection and Quarantine Council of Agriculture, Executive Yuan, Taichung,  Taiwan,Republic of China.

  25.Chao LL and Shih CM* (2002). Molecular characterization of Lyme disease spirochetes (Borrelia burgdorferi sensu      lato)isolated in Taiwan by restriction fragment length polymorphism analysis of 5S-23S intergenic spacer amplicons.    American Journal of Tropical Medicine and Hygiene 67:504-510. (SCI in Tropical Medicine)(Corresponding author).

26.Chung YC, Tsai HY, Shih CM, Chao LL and Lin RY (2002). Lyme disease in childhood:report of one case. Acta                 Paediatrica Taiwanica  43:162-165. (國科會優良期刊)

27.Tung LN, Su HY, Shih CM, Chao LL and Chen HC (2002). Multiple erythema migrans treated with minocycline accompanied with   Jarisch-Herxheimer reaction. Dermatologica Sinica 20:152-160. (國科會優良期刊)

28.Tsai HC, Lu CF, Shih CM, Chao LL and Hu CH (2002). Lyme disease during pregnancy. Dermatologica Sinica 20:147-151. (國科   會優良期刊)

29.Shih CM*, Chao LL and Yu CP (2002). Chemotactic migration of Lyme disease spirochetes (Borrelia burgdorferi) to the salivary gland extracts of vector tick. American Journal of Tropical Medicine and Hygiene 66:616-621. (SCI in Tropical Medicine)(NSC89-2320-B-016-037).

30.Shih CM* and Chao LL (2002). An OspA-based genospecies identification of Lyme disease spirochetes (Borrelia burgdorferi sensu lato) isolated in Taiwan. American Journal of Tropical Medicine and Hygiene 66:611-615. (SCI in Tropical Medicine) (NSC89-2314-B-016-082).

  31.Shih CM* and Chao LL (2002). Genetic analysis of the outer surface protein C gene of Lyme disease spirochetes (Borrelia burgdorferi sensu lato) isolated from rodents in Taiwan. Journal of Medical Microbiology 51:318-325. (SCI in Microbiology).

【研討會論文】

 1.Shih CM and Chao LL (2013). Emerging tick-borne Lyme disease in Taiwan: from discovery to molecular approach and it’s impact on National Quarantine Service. 第十屆粵港澳台預防醫學學術會議，May 25-26, 2013, Macau, China.

2.Chao LL, Lu CF, and Shih CM (2012). Molecular identification of Borrelia spirochetes isolated from skin biopsies of patients characterized with an unusual dermal manifestation (prurigo pigmentosa)in Taiwan.The 22th European Congress of Clinical Microbiology and Infectious  Diseases (Abstract 943), p., March 31-April 3, 2012, London, UK.

 3.Chao LL and Shih CM (2010). Molecular evidence of genetic diversity of Borrelia burgdorferi sensu lato detected in Ixodes granulatus ticks removed from rodents inTaiwan. 14th International Congress on Infectious Diseases (Abstract 34.009), March 9-12, 2010, Miami, USA.

 4.Shih CM and Chao LL (2009). Molecular analysis of Borrelia spirochetes detected in Ixodesgranulatus ticks removed from rodents in Taiwan. The 19th European Congress of Clinical Microbiology and Infectious Diseases (Abstract 715), p.88, May 16-19, 2009, Helsinki, Finland.

 5.Chao LL and Shih CM (2008). Genetic analysis of the flagella gene of Lyme disease spirochetes Borrelia burgdorferi isolated from offshore Kinmen Island of Taiwan. The 13th International Congress on Infectious Diseases (Abstract 40.065), p.106, June 19-22,2008, Kuala Lumpur, Malaysia.

 6.Shih CM, Yu WC, and Chao LL (2008). Molecular diagnosis of Babesia infection among rodents collected from the offshore Kinmen island of Taiwan. The 13th International Congress on Infectious Diseases (Abstract 65.039), p.166, June 19-22,2008,Kuala Lumpur, Malaysia.

 7.Shih CM, Chang MT, and Chao LL (2006). Seasonal prevalence of Ixodes granulatus (Ixodidae), a supposed tick vector for Lyme disease spirochetes, in the offshore Kinmen Island of Taiwan. The 12th International Congress of Acarology (Abstract Doelenzaal), p.189, August 21-26, 2006, Amsterdam, The Netherlands.

 8.Chao LL, Wu WJ, and Shih CM (2006). Phylogenetic analysis of Ixodes granulatus (Ixodidae) in Taiwan based on mitochondrial 16S rDNA sequences. The 12th International Congress of Acarology (Abstract F001), p.40, August 21-26, 2006, Amsterdam, The Netherlands.

 9.Chao LL , Chen YC, and Shih CM (2005). Seroepidemiology of Lyme disease infection in Taiwan. The 54th Annual Meeting of the American Society of Tropical Medicine and Hygiene (Abstract 652), p.215, December 11-15, 2005, Washington, DC, USA.

 10.Shih CM , Chen YC, and Chao LL (2005). Standardization of serodiagnosis for Lyme disease infection in the Taiwan area. The 54th Annual Meeting of the American Society of Tropical Medicine and Hygiene (Abstract 651), p.215 , December 11-15, 2005,Washington, DC, USA.

 11.Chao LL and Shih CM (2004). Enzoonotic transmission of Lyme disease spirochetes (Borrelia burgdorferi) in the offshore Kinmen island of Taiwan. The 53th Annual Meeting of the American Society of Tropical Medicine and Hygiene (Abstract 640), p.189, November 7-11, 2004, Miami Beach, Florida, USA.

 12.Shih CM and Chao LL (2004). Seroprevalence of scrub typhus infection among military personnel during their service at an endemic site of Taiwan. The 53th Annual Meeting of the American Society of Tropical Medicine and Hygiene (Abstract 639), p.189, November 7-11, 2004, Miami Beach, Florida, USA.

 13.Chao LL and Shih CM. (2003). Serosurvey of Borrelia burgdorferi infection among military personnel of Taiwan. The 8th Conference of the International Society of Travel Medicine. (Abstract PO07.01),p.170, May.7-11, 2003. New York City, USA.

 14.Shih CM and Chao LL (2003).Seroprevalence of Lyme disease infection in Taiwan. The 8th  Conference of The International Society of Travel medicine (Abstract PO04.06), p.149, May 7-11, 2003, New York, USA.

 15.Shih CM and Chao LL (2002). Common vector ticks parasitized on wild and domestic animals in Taiwan. The 10th International Congress of Parasitology (Abstract PA-035), August 4-9, 2002, Vancouver, Canada.

 16.Shih CM (2002). Current status of Lyme disease infection in Taiwan. Symposium on Emerging and Reemerging Vector-borne Human Infections, pp.39-52, November 23-26, 2002, Taipei, Taiwan.

 17.Chen YJ, Shih CM, Chao LL, and Chiu HC (2002). Serology and culture of Borrelia burgdorferi in patients with borreliosis-related dermatosis. Symposium on Emerging and Reemerging Vector-borne Human Infections, p.66, November 23-26, 2002, Taipei, Taiwan.

 18.Wang VC, Chen CC, Chao LL, and Shih CM (2002). Lyme neuroborreliosis: a patient characterized by the facial nerve palsy. Symposium on Emerging and Reemerging Vector-borne Human Infections, p.68, November 23-26, 2002, Taipei, Taiwan.

 19.Wu CC, Liang CK, Chou SY, Lee SM, Hui WM, Shih CM, and Chao LL (2002). Limbic keratoconjunctivities combining with retinitis    as characteristics of intraocular Lyme disease. Symposium on Emerging and Reemerging Vector-borne Human Infections, p.69, November 23-26, 2002, Taipei, Taiwan.

 20.Huang YL, Lee MC, Yang LJ, hong HS, Shih CM, and Chao LL (2002). The skin manifestations of Lyme disease in Taiwan: a clinical observation and experience of Chang Gung Memorial Hospital. Symposium on Emerging and Reemerging Vector-borne Human    Infections, p.70, November 23-26, 2002, Taipei, Taiwan.

 21.Chung YH, Hong HS, Shih CM, Chao LL, Huang YL, and Lee MC (2002). Vulvar lichen sclerosus and Borrelia burgdorferi infection. Symposium on Emerging and Reemerging Vector-borne Human Infections, p.71, November 23-26, 2002, Taipei, Taiwan.

 22.Lu CF, Shih CM, and Chao LL (2002). The expending clinical spectrum of skin manifestations of Lyme disease. Symposium on Emerging and Reemerging Vector-borne Human Infections, p.72, November 23-26, 2002, Taipei, Taiwan.

 23.Lin WJ, Lo WT, Lien SH, Chao LL, Shih CM, and Wang CC (2002). Erythema migrans mimicking cellulitis: report a pediatric case of Lyme disease in Taiwan. Symposium on Emerging and Reemerging Vector-borne Human Infections, p.73, November 23-26, 2002, Taipei, Taiwan.

 24.Chung YC, Tsai HY, Shih CM, Chao LL, and Lin RY (2002). Lyme disease in childhood:a case report. Symposium on Emerging and Reemerging Vector-borne Human Infections, p.74, November 23-26, 2002, Taipei, Taiwan.

【專書】

 1.Shih CM and Chao LL (2011). A catalog of Ixodidae ticks of Taiwan. Department of Parasitology and Tropical Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China (This publication was sponsored by the National Science Council, Taipei, Taiwan, Republic of China).