(一)、基本資料

姓名：邱 式 鴻

服務機關：高雄醫學大學醫學研究所

職稱：教授

出生地：新竹市

通訊地址：高雄市十全一路高醫大醫學研究所第一教學大樓Rm.1101

辦公室：電話：(07)322-0377        傳真：(07)313-3434

住宅：(07)716-3086

信箱：shchiou@kmu.edu.tw

（二）、學歷

畢業學校	國別	科系所或主修學門	學位
國立臺灣大學	臺灣	藥學系	學士
國立臺灣大學	臺灣	化學研究所	碩士
美國科羅拉多州立大學	美國	生化研究所	博士
美國哈佛大學医學院	美國	血液學科研究部	研究員

（三）、經歷

服務機關	服務部門	職稱
萊納斯鮑林科學及醫學研究所	生化藥理研究部	資深研究員
國立臺灣大學	生化科學研究所	終身特聘教授
中央研究院	生物化學研究所	資深研究員

（四）、曾獲得榮譽或獎勵

獎項名稱	設獎(主辦)單位	年度	獎金金額
傑出研究獎	行政院國家科學委員會	1988	300,000 NT
傑出研究獎	行政院國家科學委員會	1990	300,000 NT
傑出研究獎	行政院國家科學委員會	1992	300,000 NT
傑出研究獎	行政院國家科學委員會	1994	300,000 NT
特約研究獎	行政院國家科學委員會	1997-2003	研究計畫獎助

Curriculum Vitae

                                         邱式鴻

Thomas S.-H. Chiou, Ph.D.

Graduate Institute of Medicine                                  Institute of Biological Chemistry

Kaohsiung Medical University                                  Academia Sinica 

Kaohsiung, Taiwan 807                                              Taipei, Taiwan 114                       

__________________________________________________________________________

Telephone: 886-(07)-3121101~2728                          Fax: 886-(07)-3133434

Background Status: Born in Hsinchu, Taiwan (August 28, 1947); married with two children.

1971 B.S.          National Taiwan University, Pharmaceutical Science

1974 M.S.         National Taiwan University, Organic Chemistry

1979 Ph.D.         Colorado State University, Biochemistry

1979-81             Research Fellow, Harvard Medical School

1981-82             Research Associate, Stanford Magnetic Resonance Laboratory, Stanford        University

1982-84             Research Scientist, Linus Pauling Institute of Science and Medicine

1985-2008,       Professor of Biochemistry, Institute of Biochemical Sciences, National   Taiwan University

1986-present,  Joint Appointment as Senior Research Fellow, Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan

1990-1991          Visiting Professor, School of Chemistry & Biochemistry, Georgia                   Institute of Technology, Atlanta, Georgia U.S.A.

1988-1996          Recipient of Outstanding Research Award, National Science Council

1996-1997          Visiting Professor, College of Chemistry, Univ. of California at Berkeley       Visiting Professor, Dept. Biochem. Mol. Biol., Colorado State University

1997-2003        Recipient of Special Project Award with Merit, National Science Council 2001-2002     Associate Director, Institute of Biological Chemistry, Academia Sinica,     Taipei, Taiwan

2002-2005         Professor and Director, Institute of Biochemical Sciences, National Taiwan    University, Taipei, Taiwan

2006-2007         Visiting Professor, Dept. of Bioengineering, Univ. of California at San Diego

2006-2008         Tenured Chair Professorship, National Taiwan University, Taipei, Taiwan

2009-present     Special Chair Professor, Kaohsiung Medical University, Kaohsiung, Taiwan

Honors & Memberships:  Listed on 2000 Outstanding Scientists of the 21st Century by the International Biographical Center in Cambridge, England; Member of American Society of Mass Spectrometry (ASMS), Biochem. & Mol. Biol. Society/ Taiwan., and Taiwan Proteomics Society.

Major Research Background and Interests:

1. Proteomic analysis of proteins expressed by Helicobacter pylori under various environmental stresses.

2. Study and screening of daily nutrients and conventional herbal medicine with therapeutic potential by using the nematode Caenorhabditis elegans as a model organism.

3. Study of crystallin aggregation in relation to amyloid formation.

4. Structural and functional characterization of snake venom toxins.

5. Development of protein-based antihypertension and antithrombotic agents. (Fibrinogenolytic proteases with thrombolytic and antihypertensive activities from Taiwan habu: Medical application and novel process of expression and production, US patent filed, Aug. 24, 2001, US patent issued Oct. 7, 2003, Patent #US 6630139 B2).

6. Wong, C.-H.Chuang, M.-H., Yang, W.-B., and Chiou, S.-H. (2009) Longevity- promoting effects of acetic acid and Reishi polysaccharide.

US Patent Application No. 12/425,319 (filed 4-16-2009)

PCT Patent Application No. PCT/US09/40879 (filed 4-16-2009)

Japanese Patent Application No. 2011505217 (filed 4-16-2009)

Representative Publications (2005-present):

A. Refereed Papers

127.  Chiou, S.-H. and Chen, Y.-S. (2005) Characterization of two major families of fibrinogenolytic proteases from the venom of Taiwan habu with special reference to their medical applications. J. Toxicol. Toxin Rev. 24, 43-61.

128.  Chuang, M.-H., Wu, M.-S., Lin, J.-T., and Chiou, S.-H. (2005) Proteomic analysis of proteins expressed by Helicobacter pylori under oxidative stress. Proteomics 5, 3895-3901.

129.  Chuang, M.-H.,Wu, M.-S., Lo, W.-L.,Lin, J.-T., Wong, C.-H.and Chiou, S.-H. (2006) The antioxidant protein alkylhydroperoxide reductase of Helicobacter pylori switches from a peroxide reductase to a molecular chaperone function. Proc. Natl. Acad. Sci. USA 103, 2552-2557.

130.  Wu, M.-S., Chow, L.-P., Lin, J.-T., and Chiou, S.-H. (2008) Proteomic identification of biomarkers related to Helicobacter pylori-associated gastroduodenal disease: Challenges and opportunities. J. of Gastroenterol. Hepatol. 23, 1657–1661.

131. Wu, M.-S., Chow, L.-P., Lin, J.-T., and Chiou, S.-H. (2008) The Application of proteomics technology to Helicobacter pylori – associated gastroduodenal disease: State-of-the-art and future clinical potentials. In: Yamaoka Y, ed. Helicobacter pylori Molecular Genetics and Cellular Biology. Norfolk: Caiser Academic Press, 245–255.

132.  Chuang, M.-H.,Chiou, S.-H.*, Huang, C.-H. Yang, W.-B., and Wong, C.-H.* (2009) The lifespan-promoting effect of acetic acid and Reishi polysaccharide. Bioorg. Med. Chem.17, 7831-7840.

133.  Wong, C.-H.Chuang, M.-H., Yang, W.-B., and Chiou, S.-H. (2009) Longevity- promoting effects of acetic acid and Reishi polysaccharide.

US Patent Application No. 12/425,319 (filed 4-16-2009)

PCT Patent Application No. PCT/US09/40879 (filed 4-16-2009)

Japanese Patent Application No. 2011505217 (filed 4-16-2009)

1. COOH-terminal truncations and site-directed mutations enhance thermostability and chaperone-like activity of porcine aB-crystallin. Mol. Vision 15, 1429-1444.
2. Ho, P.-Y., Chueh, S.-C., Chiou, S.-H., Wang, S.-M., Lin, W.-C., Lee, I.-L., Yang, H.-Y., Peng, H.-C., and Lai, M.-K. (2013) aB-Crystallin in clear cell renal cell carcinoma: Tumor progression and prognostic significance. Urologic Oncology 31, 1367-1377.

135.  Chen, Y.-S., Huang, C.-H., and Chiou, S.-H. (2010) Characterization and molecular cloning of one novel C-type lectin from the venom of Taiwan habu (Trimeresurus mucrosquamatus). Toxicon 55, 762-772.

136.  Huang, C.-H., Lee, I-L., Yeh, I.-J., Liao, J.-H., Ni, C.-L., Wu, S.-H., and Chiou, S.-H. (2010) Upregulation of a non-heme iron-containing ferritin with dual ferroxidase and DNA-binding activities in Helicobacter pylori under acid stress. J. Biochem. 147, 535-543.

137.  Huang, C.-H., Chuang, M.-H., Wu, Y.-H., Chuang, W.-C., Jhuang, P.-J., and Chiou, S.-H.  (2010) Characterization of site-specific mutants of alkylhydroperoxide reductase with dual functionality from Helicobacter pylori J. Biochem. 147, 661-669.

138.  Chiou, S.-H., Huang, C.-H., Lee, I.-L., Wang Y.-T., Liu, N.-Y., Tsay, Y.-G., and Chen Y.-J., (2010) Identification of in vivo phosphorylation sites of lens proteins from porcine eye lenses by a gel-free phosphoproteomics approach. Mol. Vision 16, 294-302.

139.  Huang, C.-H., Wang, Y.-T., Tsai, C.-F., Chen, Y.-J., Lee, J.-S., and Chiou, S.-H. (2011) Phosphoproteomics characterization of novel phosphorylated sites of lens proteins from normal and cataractous human eye lenses. Mol. Vision 17, 186-198.

140.  Chiou, S.-H. and Wu, C.-Y. (2011) Clinical Proteomics: Current Status, Challenges and Future Perspectives. Kaohsiung J. Med. Sci. 27, 1-14.

141.  Huang, C.-H., Chuang, M.-H.,Lo, W.-L., Wu, M.-S., Wu Y.-H., Wu, D.-C., and Chiou, S.-H. (2011) Alkylhydroperoxide reductase of Helicobacter pylori as a biomarker for gastric patients with different pathological manifestations.Biochimie 93, 1115-1123.

142.  Huang, C.-H., and Chiou, S.-H. (2011) Proteomic analysis of upregulated proteins in Helicobacter pyloriunder oxidative stress induced by hydrogen peroxide. Kaohsiung J. Med. Sci. 27, 544-553.

144.  Liao, J.-H., Sun, Y.-H., Hsu, C.-H. Lin, Y.-C., Wu, S.-H., Kuo, C.-J., Huang,C.-H. and Chiou, S.-H. (2013) Up-regulation of neutrophil activating protein in Helicobacter pylori under high-salt stress: Structural and phylogenetic comparison with bacterial iron-binding ferritins. Biochimie 95, 1136-1145.

145.  Lin,Y.-R., Mok, H.-K., Wu,Y.-H., Liang,S.-S.,Hsiao, C.-C., Huang, C.-H., and Chiou, S.-H. (2013) Comparative proteomics analysis of degenerative eye lenses of nocturnal rice eel and catfish as compared to diurnal zebrafish. Mol. Vision 19, 623-637.

146.Kuo, C.-J., Liang, S.-S., Hsi, E., Lin, S.-D., and Chiou, S.-H. (2013)Quantitative proteomics analysis of varicoseveins: Identification of a set of differentially expressed proteins related to ATP generationand utilization.Kaohsiung J. Med. Sci. 29, 594-605.

147. Chiou, S.-H., Lee, M.-Y., Kuo, C.-J., and Liang, S.-S. (2013) Application of quantitative proteomics to disease diagnosis and prognosis using stable isotope dimethyl labeling coupled with shotgun proteomics strategy and multiple reaction monitoring. In: Recent Advances in Proteomics Research (Ed., M.D. Li), pp. 119-137, Nova Science Publishers, Inc. New York, U.S.A.

148.Liang, S.-S., Kuo,C.-J., Chi,S.-W., Wu, W.-J., Chen, S.-T., and Chiou, S.-H. (2013)Quantitative proteomics analysis of differentially expressed proteins involved in renal clear cell carcinoma by shotgun approach coupled with stable isotope dimethyl labeling. J. Proteomics Bioinform. S7: 003. doi:10.4172/jpb.S7-003

149.  Huang, C.-H., and Chiou, S.-H. (2014) Clinical Proteomics identifies potential biomarkers in Helicobacter pylori for gastrointestinal diseases.World J. Gastroenterol. 20, 1529-1536.

150.  Kuo, C.-J., Wang, S.-N., Liang, S.-S., Chi,S.-W., Yu, Z. J., Hsi, E., Lee, K.-T., and Chiou, S.-H. (2014)Shotgun Proteomics Analysis of Differentially Expressed Urinary ProteinsInvolved in the Hepatocellular Carcinoma. J. Proteomics Bioinform. 7: 034-040. doi:10.4172/jpb.1000300

151.  Lee, M.-Y., Kuo, C.-J., Chen, W.-J., Huang, C.-H., Lin, C.-L. S., Lai, W.-T., and Chiou, S.-H. (2014) Urinary soluble CD14 is a potential novel biomarker for diagnosis of stable coronary artery disease. Biochimie Submitted for Publication

152.  Huang,C.-H., Huang, Y.-S., Li, J. Y.-S., Haga, J. H., Kuo, C.-J., Chien, S., and S.-H. Chiou (2014) Kinetic proteomics analysis of vascular endothelial cells under laminar shear stress. Submitted for Publication