Author:
Chin-Chuan Chang, Chao-Jung Chen, Wen-Ling Hsu, Shu-Min Chang, Ying-Fong Huang, Yu-Chang Tyan
Abstrast:
To investigate the prognosticsignificance of metabolicparameters and texture analysis on 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in patients with breastinvasiveductalcarcinoma (IDC), from August 2005 to May 2015, IDC patients who had undergone pre-treatment FDG PET/CT were enrolled. The metabolicparameters, including maximal standardized uptake value of breast tumor (SUVbt) and ipsilateral axillary lymph node (SUVln), metabolic tumor volume (MTVbt) and total lesion glycolysis (TLGbt) of breast tumor, whole-body MTV (MTVwb) and whole-body TLG (TLGwb) were recorded. Nine texturalfeatures of tumor (four co-occurrence matrices and five SUV-based statistics) were measured. The prognosticsignificance of above parameters and clinical factors was assessed by univariate and multivariate analyses. Thirty-five patients were enrolled. Patients with low and high MTVwb had 5-year progression-free survival (PFS) of 81.0 and 14.3% (p < 0.0001). The 5-year overall survival for low and high MTVwb was 88.5% and 43.6% (p = 0.0005). Multivariate analyses showed MTVwb was an independent prognostic factor for PFS (HR: 8.29, 95% CI: 2.17-31.64, p = 0.0020). The SUV, TLG and texturalfeatures were not independently predictive. Elevated MTVwb was an independent predictor for shorter PFS in patients with breast IDC
Subject terms:
Breast cancer, Epidemiologyocal recurrence; locallyadvancedrectal cancer; neoadjuvantchemoradiotherapy; surgery